hierarchical clustering and heatmap viewer user-interface (Zambon)
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Hierarchical Clustering And Heatmap Viewer User Interface, supplied by Zambon, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf"
Article Title: Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf
Journal: Developmental biology
doi: 10.1016/j.ydbio.2017.11.006
Figure Legend Snippet: A) De novo identified cell populations from the software ICGS are shown for each scRNA-Seq platform. The displayed heatmaps were produced by the MarkerFinder algorithm, downstream of the ICGS population predictions, with yellow indicating high relative gene expression and blue or black, low or no gene expression in the associated genes (rows). Prior established embryonic kidney marker genes corresponding to compartments are shown in panel C. Text to the left of each heatmap indicates the statistical enrichment of genes from the Drop-Seq ICGS analysis for the 16 identified populations (MarkerFinder) using the embedded gene-set enrichment analysis tool GO-Elite in AltAnalyze. B–C) t-SNE plot derived from the ICGS heatmaps in panel A, where each dot represents individual cells colored according to its B) ICGS cluster annotation or C) prior established population specific genes. CD: Collecting duct, UT: Ureteric Tip, LOH: Loop of Henle, RV: Renal vesicle, DCSB: Distal comma shaped body, Pod: podocyte, PT: Proximal Tubule, PA: Pre-tubular aggregate, CM: Cap mesenchyme, Endo: Endothelium, NZS: Nephrogenic Stroma, CS: Cortical Stroma.
Techniques Used: Software, Produced, Gene Expression, Marker, Derivative Assay
Figure Legend Snippet: Heatmap with representative cells from the CM: cap mesenchyme, PA: pretubular aggregate, DCSB: distal comma shaped body, MSSB: mid S-shaped body, PT: proximal tubule, LOH: loop of Henle, and Pod: Podocyte clusters from Drop-seq, Chromium 10X Genomics, and Fluidigm 800-cell. The early progenitor CM cells show stochastic expression of markers of multiple lineages. The MSSB cells are more committed and show elevated expression of proximal tubule associated genes and reduced expression of podocyte marker genes.
Techniques Used: Expressing, Marker
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Software:Article Title: Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf Article Snippet: Gene set enrichment analysis of ToppGene defined GUDMAP genes was performed using the GO-Elite option in the hierarchical clustering and Produced:Article Title: Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf Article Snippet: Gene set enrichment analysis of ToppGene defined GUDMAP genes was performed using the GO-Elite option in the hierarchical clustering and Gene Expression:Article Title: Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf Article Snippet: Gene set enrichment analysis of ToppGene defined GUDMAP genes was performed using the GO-Elite option in the hierarchical clustering and Marker:Article Title: Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf Article Snippet: Gene set enrichment analysis of ToppGene defined GUDMAP genes was performed using the GO-Elite option in the hierarchical clustering and Derivative Assay:Article Title: Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf Article Snippet: Gene set enrichment analysis of ToppGene defined GUDMAP genes was performed using the GO-Elite option in the hierarchical clustering and Expressing:Article Title: Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf Article Snippet: Gene set enrichment analysis of ToppGene defined GUDMAP genes was performed using the GO-Elite option in the hierarchical clustering and |